In May 2019, an international conference on perinatal palliative care entitled “Yes to Life! Taking Care of the Precious Gift of Life in Its Frailty” was held in Rome. It was organized by the Italian nonprofit foundation Il Cuore in Una Goccia and the Vatican’s Dicastery for Laity, Family and Life. Pope Francis greeted the participants personally and delivered an address describing the goals and practices of perinatal palliative care as being in keeping with the teachings of the Roman Catholic (...) Church and the pastoral care of families. His endorsement represents a new pastoral development, a renewed focus on supporting families and infants who are affected by genetic... (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Die sog. "Schwarzen Hefte" haben umfassender und deutlicher als je zuvor die Verbindungen zwischen Philosophie und Politik bei Heidegger sichtbar werden lassen und damit eine neue Debatte uber den Rang dieses Denkens entfacht. DEnn die dort enthaltenen Texte demonstrieren, dass Philosophie, Metapolitik und Politik bei Heidegger eine Einheit bilden, zu der die Befurwortung des Nationalsozialismus und der Antisemitismus gehoren. INs Zentrum der kritischen Revision ruckt das erste Hauptwerk von 1927, "Sein und Zeit", das nahezu unangefochten als epochaler Beitrag zur Philosophie (...) des 20. JAhrhunderts gilt. DIe "Schwarzen Hefte" fordern eine "Destruktion" dieses Werks auch insofern heraus, als die dort prasentierten Selbstinterpretationen das philosophische Profil dieses Denkens scharfen und neue Gesichtspunkte fur die Diskussion seiner Substanz im philosophischen und ideologischen Kontext des 20. JAhrhunderts eroffnen. 90 Jahre nach seinem Erscheinen stellt sich der philosophischen Forschung die kritische Auseinandersetzung mit "Sein und Zeit" als unabweisbare Aufgabe. IM Vordergrund stehen hierbei zwei Fragen: Wie ist das Unternehmen einer in der "Fundamentalontologie" des Daseins begrundeten temporalen Ontologie der systematischen Intention und Durchfuhrung fachphilosophisch zu beurteilen? Beinhalten die ausgearbeiteten Teile bereits gedankliche Prafigurationen oder Grundlagen fur Heideggers Antisemitismus und Nationalsozialismus? Der Band behandelt diese Problemstellungen aus unterschiedlichen philosophischen, aber auch disziplinaren Perspektiven; er enthalt Beitrage von Charles Bambach, William Blattner, Christoph Demmerling, Emmanuel Faye, Anton M. FIscher, Johannes Fritsche, Hassan Givsan, Marion Heinz, Christoph Jamme, Sidonie Kellerer, Rainer Marten, Daniel Meyer, Livia Profeti, Tom Rockmore und Dieter Thoma. (shrink)

Thomas Aquinas produced a voluminous body of work on moral theory, and much of that work is on virtue, particularly the status and value of the virtues as principles of virtuous acts, and the way in which a moral life can be organized around them schematically. Thomas Osborne presents Aquinas's account of virtue in its historical, philosophical and theological contexts, to show the reader what Aquinas himself wished to teach about virtue. His discussion makes the complexities of Aquinas's (...) moral thought accessible to readers despite the differences between Thomas's texts themselves, and the distance between our background assumptions and his. The book will be valuable for scholars and students in ethics, medieval philosophy, and theology. (shrink)

This volume commemorates the 6th centennial of the birth of Nicholas of Cusa (1401-1464), a Renaissance polymath whose interests included law, politics, metaphysics, epistemology, theology, mysticism and relations between Christians and non-Christian peoples. The contributors to this volume reflect Cusanus' multiple interests; and, by doing so they commemorate three deceased luminaries of the American Cusanus Society: F. Edward Cranz, Thomas P. McTighe and Charles Trinkaus. Contributors include: Christopher M. Bellitto, H. Lawrence Bond, Elizabeth Brient, Louis Dupré, Wilhelm Dupré, Walter (...) Andreas Euler, Lawrence Hundersmarck, Thomas M. Izbicki, Dennis D. Martin, Yelena Matusevich, Bernard McGinn, Clyde Lee Miller, Thomas E. Morrissey, Brian A. Pavlac, and Morimichi Watanabe. Publications by Charles Trinkaus: - Edited by C. Trinkaus and H.A. Oberman, The pursuit of holiness in late medieval and renaissance religion, ISBN: 978 90 04 03791 5 (Out of print). (shrink)

El relativismo acerca de las atribuciones de conocimiento de John MarFarlane pretende ser una teoría que explica la corrección de las intuiciones centrales que tenemos acerca de ellas. Sin embargo, el relativismo es incompatible con la corrección de algunas intuiciones que tenemos con respecto a casos de Stanley, a conjunciones de estos casos y a casos en los que la situación práctica del evaluador es menos apremiante que la del sujeto o la del emisor de la atribución. Esto, no obstante, (...) no señala un límite a las posibilidades del relativismo, sino que insta a dar versiones más sofisticadas del mismo. MarFarlane's relativism about knowledge attributions aspires to be a theory that explains why the central intuitions about them are correct. Nevertheless, relativism is incompatible with the accuracy of some intuitions about Stanley's cases, with conjunctions of them and with intuitions about cases in which there is less at stake from the assessor than what is at stake from the subject or the attributor. Nevertheless, this doesn't establish a limit to the possibilities of relativism, but calls for an improvement of it. (shrink)

Leibniz avait certes raison d'opposer Locke à Descartes et de le situer plutôt dans la lignée de Gassendi et l'atomisme antique. Mais le problème est de distinguer entre Gassendi et ses disciples contemporains de Locke comme source immédiate d'inspiration pour celui-ci. Ses Commonplace Books attestent que Locke avait lu Gassendi avec attention, et son Journal indique que pendant ses séjours à Paris, il fut en contact avec des gassendistes tels Bernier et Launay, dont il acheta les oeuvres pour les emporter (...) en Angleterre. L'analyse que Locke fournit de l'espace est d'un intérêt particulier, car tout en témoignant de l'orientation que Leibniz attribuait à Locke, elle s'écarte nettement des vues de Gassendi sur la question. (shrink)

Readers have found at least two distinct and perhaps contradictory accounts of civil authority in the works of Francisco de Vitoria, and some hold that Vitoria himself holds contradictory positions. This article argues that Vitoria holds one consistent position, namely that civil power is based on a necessity that is rooted in human nature, and in particular on the final cause of human life, and not on a necessity that is a result of any historical decision or process on its (...) own. Rulers receive from the community their authority, which is a power to act on behalf of the community. In general, scholars have failed to consider how Vitoria’s understanding of civil power is Aristotelian and Thomistic to the extent that it is based on the thesis that the political community is natural in a way similar to how families and individuals are natural. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:119. HUME'S CONDITIONS FOR' CAUSATION: FURTHER TO GRAY AND IMLAY As part of his second proof of the existence of God, Descartes in Meditations III argues a causal premise derived from the nature of time. He argues it follows from the nature of time "that, in order to be conserved in each moment in which it endures, a substance has need of the same power and action as would (...) be necessary to produce and create it anew, supposing it did not yet exist; so that the light of nature shows us clearly that the distinction between creation and conservation is solely a distinction of reason." The nature of time to which he refers allows only a finite divisibility into durationless moments, each of which is entirely independent of every other. In the ultimate analysis, nothing true of one moment is deducible from what is true of any other, even what happens to be eternally true. The doctrine of the creation of the eternal verities is of a piece with this conception of time, and following with it from the conception of the divinity as sheer omnipotence, points to Hume's view that experience is the only guide to the world. It would seem to be Descartes' view, that nothing at a given time can stand in the necessary relation it must have to be a cause of something at another time; or, only something outside time can be a cause, for whose operation things in time can serve as but occasions. To what extent this dialectic in fact led to later occasionalist views is an historical question we need not consider. My only suggestion here concerns Hume's réponse to the occasionalists. With all but psychological necessity eliminated from his analysis of causation, Hume effectively argues the familiar case that occasional causes are the only causes by arguing the finite divisibility of time. In the literature only Laporte has held that for Descartes time is infinitely divisible and in this sense continuous. The separability of the parts of time, he 120. thought, suffice for their independence and contingency. But if time is continuous, its parts are inseparable; as Gueroult correctly observes, by discontinuity is meant con2 tingence, independence and separability. In addition, if a moment had duration, light would not be propagated instant aneously, thus according to Descartes upsetting his entire 3 physics. Gueroult maintains, rather, that Descartes' view of time is determined by his view of motion. Whatever the historical and logical priorities, there clearly is a connection between the above and what Bergson called the cinematographic conception of motion as a succession of static objects. It is a conception that precludes events as such. Motion occurs only in time, never at the moment, and occurs as a result of the re-creation of matter with regularly differing spatial relations. Due to metaphysical consideration expressed in theological terms, especially with reference to the immutability and simplicity of divine ways, this recreation of matter is constrained in certain ways, some of which we pick out as conditions for what was later called occasional causation. Put very simply, only what is constantly conjoined can stand in this relation; and that there should be instances of constant conjunction follows from the metaphysical considerations. With Hume's elimination of these metaphysical considerations, the status of the conditions, which he takes over as conditions for causation simpliciter, becomes problematic. But a recent challenge to Hume's program is still more problematic. The contention is that there is a case in which Hume's conditions necessary fo constant conjunction cannot all be satisfied. Even worse, i is a case in which his analysis ought to be conspicuously successful, viz. collision, which Hume like Descartes con4 ceives in cinematographic terms. The aim of this paper is to show that Hume's analysis stands against the challenge. Consider the following diagram which illustrates the positions (A3, A_...) of two balls (x,y) at successive moments (t_, t.,...)· 121. A3 A2 A1 A B -B1 B2 B3 fc0 T T T ©© © G®©T©T h fc3 fc4 fc5 H Robert Gray's thesis is that in at least one case of causation, collision which results in... (shrink)

RésuméLe Dr French résume ici très briévement les idées développées dans un ouvrage qu'il publiera prochainement sous le titre Intégration of behavior . – Le comportement comprend deux aspects essentiels que ľon peut désigner des termes de motivation et compréhension intelligente {insight). Cette dernière àété admirablement analľsée par ľécole gestaltiste , qui à cependant eu le tort de la présenter comme de soi consciente. Or, il ľà des insights inconscients, áľœuvre par exemple dans ľacquisition des réflexes conditionnels, des habiletés motrices (...) et de certaines réactions pathologiques. Conscient ou inconscient, ľinsight implique un groupement sľstématique des données sensorielles, non plus considérées isolément, mais mises en relation les unes avec les autrès.La manifestation la plus simple ?insight est la construction ?un champ cognitif qui choisit et groupe les données élémentaires, et fait répondre, non plus à ces données séparément, mais à leur groupement. Le cognitive field peut demeurer purement cognitif. II prend le nom de champ intégratif lorsqu'il exerce une influence régulatrice sur le comportement. Ces champs intégratifs ne restent pas isolés. lis interfèrent et se combinent entre eux, par exemple dans ľaction à long terme, par un processus de résonance ou ?induction mutuelle. Ceci joue notamment dans les cas ou ľindividu fait des plans relativement à un but éloigné. Une induction mutuelle s'établit alors entre le champ de ľimagination et celui de la réalité et de la perception.Champs cognitifs et intégratifs sont activeés par des pressions motivationnelles ?intensité variable. II faut ici distinguer entre pressions purement négatives, qui poussent ľindividu àéchapper à un état de dissatisfaction et tendent à se décharger en activités musculaires diffuses, et pressions positives, stimulées par ľespoir et par la présence ou le souvenir ?une satisfaction possible dans ľenvironnement. Besoins et espoirs jouent dans le comportement un rôle complémentaire. Ľespoir substitue á la primitive décharge motrice caractéristique des besoins, une activité canalisée et orientée vers le but. Ceci, qui peut être inné dans les espèces animales inférieures, est chez ľhomme matière ?apprentissage. Pour atteindre un but, ľhomme doit apprendre á inhiber les décharges motrices originelles, et á leur substituer une conduite guidée par ľespoir, les mécanismes ?intégration et la construction de plans.Le succès de cette entreprise dépend de ľintensité de la pression motivationnelle. Si celle‐ci dépasse certaines limites , les mécanismes ?intégration et ?élaboration de plans sont rendus plus difficiles et Ľindividuperd la tête, c'est‐à‐dire que Ľinsight régulateur ne peut plus contrôler les décharges motrices. Comme c'est ľespoir du succès qui déclenche le travail ?intégration et de prévision, la capacityé?intégration ?un individu dans une circonstance donnée augmente en proportion de ses espoirs de succès et diminue en proportion de ses appréhensions ?échec.Ces considérations nous acheminent jusqu'aux réactions pathologiques, névrotiques et psychotiques, dont s'occupe la psychanalyse. Dans ces comportements irrationnels, les mécanismes ?intégration ont, sous ľeffet des facteurs qui viennent ?être indiqués, subi une sorte de fragmentation, suivie ?habitude par des réintégrations partielles de certains de leurs fragments. (shrink)

Anthropology is turning toward a new engagement with acentral question of Weber: how do people come to understand the distributionof fortune in the world? Our discipline’s recent examination ofthe uses of the past prompts us to ask how stances toward the future areboth the product of cultural logics and the target of institutional interests.In this article, I trace the engagement with contingency in anthropologyand social thought, and then compare the nonchalant stance toward thefuture found in Greek society with the different (...) disposition of individualgaming mastery in the digital domain, such as in Second Life, but alsoin the longest-running Greek state-sponsored game: Pro-Po. These examplesillustrate how games are increasingly the sites for institutional effortsboth to appropriate creativity and to generate distinctive subjectivities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Persuasion and RhetoricThomas M. ConleyPersuasion and Rhetoric. Carlo Michelstaedter. Translated with an introduction and commentary by Russell Scott Valentino, Cinzia Sartini Blum, and David J. Depew : New Haven: Yale University Press, 2004. Pp. 178. $32.50, hardcover.Readers of this book will not find much in it about the "persuasion" and "rhetoric" they might expect to read about in this journal. Nor will they find in it the Appendici (...) Critiche that appear in the original text, Michelstaedter's thesis entitled I concetti di persuasione e rettorica [sic] in Platone e Aristotele, which he submitted to the Faculty of Letters in Florence in 1910. But the version printed here by the editors (hereafter "VBD," as there is no indication of who did what) will no doubt appeal to those who dislike Plato and Aristotle, have the idea that something better can be found in the Presocratics, and claim allegiance to such philosophers as Schopenhauer, Nietzsche, and the Heidegger of Being and Time; for this is a book about the problem of attaining a sort of existential "authenticity" and not, in my view, "one of the most trenchant and influential studies in modern rhetoric," as the liner notes claim. To be sure, Persuasione e rettorica has been the subject of decades of contentious scholarship in Italy. But most of that scholarship (and that displayed in the headnotes provided by VBD) concerns the sources of Michelstaedter's ideas and his true debt to the likes of Parmenides and Heraclitus, both of whom figure significantly in his worldview."Persuasione"—and I use the Italian here to avoid confusion—might best be understood to mean a sort of self-possession, being at one with oneself and with the world, or what I called before "authenticity." Michelstaedter himself never makes an effort to define it, for to do that would be to turn it into the sort of abstraction that Michelstaedter opposes. Defining things, as we learn from the Appendici, is the sort of thing philosophers like Aristotle and Hegel do in an act of bad faith or delusion. "Persuasione" is, by contrast, something lived, not understood—or, more precisely, it is a state to which true philosophers (Parmenides and Socrates, for instance) aspire with the full understanding that, like the limit approached asymptotically by an hyperbola (see 48, 109), it can never be attained. That understanding was replaced by the false consciousness represented by the "rettorica" taught by the Sophists and Plato (along with his disciple, Aristotle), and continues to the present day. This account is hinted at in the "Historical Example" allegory of the present text (77–84); but is more fully "documented" in a section of the long Appendix 2, "Note alla triste historia" (107–56 in the 1972 Raschini edition), entitled "La decadenza" (129–35). [End Page 170]"Rettorica," then, is the name Michelstaedter gives to the whole range of ingenious linguistic devices we use to convince ourselves that we are satisfied, fulfilled, secure in our selves and in the world—i.e., "persuaded"—when we are only suffering from a delusion created by language itself. It is rettorica that gives rise to "commonplaces" that masquerade as true understanding, to the impostures of "science" in the name of "objectivity" (see 89–95), to technology and machines, to "education" (110–11, 148–52), and indeed to every manifestation of bourgeois ideology (see the "dialogue" at 104–6, for instance). Rettorica is a kind of hypocrisy, deception, and (self-) flattery; an instrument of "the community of the wicked" (100, 143), a collection of "ornaments of the darkness" (e.g., 137, 139).The problem we face in acknowledging all this is, of course, that the attempt to articulate it has to be done in language; and language, by its very nature in all its semantic and syntactic elements (the point of Appendix 1, Raschini, 103–6), subverts true "persuasione." How can one "speak truth to authenticity," so to speak, when one begins by "giving a name to" its contrary, "rettorica"?"Trenchant," in any event, is hardly the right term to describe Persuasion and Rhetoric. "Mordant" or "plangent" might be closer to the mark. And as for its influence on "modern rhetoric... (shrink)

Thomas A. Fay Heidegger and the Formalization of Thought 1 Dagfinn F011esdal The Justification of Logic and Mathematics in Husserl's Phenomenology 25 Guillermo E. Rosado Haddock On Husserl's Distinction between State of Affairs and Situation of Affairs.... 35 David Woodruff Smith On Situations and States of Affairs 49 Charles W. Harvey, Jaakko Hintikka Modalization and Modalities................... 59 Gilbert T. Null Remarks on Modalization and Modalities 79 J. N. Mohanty Husserl's Formalism 93 Carl J. Posy Mathematics as a Transcendental Science (...) 107 vi Gian-carlo Rota Mathematics and the Task of Phenomenology 133 John Scalon "Tertium Non Datur: " Husserl's Conception of a Definite Multiplicity..... 139 Thomas M. Seebohm Psychologism Revisited 149 Gerald J. Massey Some Reflections on Psychologism 183 Robert S. Tragesser How Mathematical Foundation all but come about: A Report on Studies Toward a Phenomenological Critique of Godel's Views on Mathematical Intuition.. 195 Kenneth L. Manders On Geometric Intentionality 215 Dallas Willard Sentences which are True in Virtue of their Color... 225 John J. Drummond Willard and Husserl on Logical Form 243 Index of Names 257 Index of Subjects 259 PREFACE The phenomenology of logic and ideal objects is the topic of Husserl's Logical Investigations. This book determined the early development of the so called phenomenological movement. It is still the main source for many phenomenologists, even if they disagree with Husserl's transcendental turn and developed other phenomenological positions or positions beyond phenomenology he early sense. (shrink)

Thomas L. Friedman's recent book on globalization, The Lexus and the Olive Tree, sees a religious value in globalization: “globalization emerges from below … from people's very souls and from their deepest aspirations” (1999, 338). Pierre Teilhard de Chardin made similar claims in 1920, calling globalization the “deep‐rooted religious movement of our age” (Teilhard 1979, 211). He came to this awareness through his experience in World War I. There he began connecting globalization to its roots in evolution and to (...) the mystics’ desire for the “All,” a desire he saw animating the work of believing and unbelieving scientists. He found confirmation of his ideas in the letters of Saint Paul, who told of God eventually filling all things. Teilhard used the vocabulary of mysticism to describe global developments in technology, industry, politics, and the environment, and the ardor of his texts has led to their being widely used for secular gatherings on global subjects. (shrink)

Despite Glouberman—s paper, I adhere to the terms I used earlier to describe the contest between Descartes and Gassendi (and their followers—which was the major part of my argument, unexamined by Glouberman). His attribution to me of a positivist conception of philosophical activity, I claim, better characterizes his own attitude toward evidence, truth, and the cognitive significance of metaphysical claims. Part of what was at stake between Descartes and Gassendi was a communal model of knowledge; within this context, I raise (...) questions about standards of scholarship and their significance. (shrink)

One of the most curious events in Othello is the titular character’s epileptic fit, which does not appear in the story by Cinthio that is the accepted source of the play’s plot. Why does Shakespeare invent such an incident? The easiest direction to take is the equation of epilepsy with demonic possession, a common belief in the early modern period. In this essay, however, I argue from textual and critical evidence for a philosophical interpretation of Othello’s epilepsy: namely, that his (...) seizure, particularly in relation to the play’s conflict of reason and emotion, can be seen as a challenge to early modern orthodoxy concerning the mind-body problem, in that it conflates the distinction between body and soul. (shrink)

Appeals to nationalism based on a common sociocultural, geographic, and linguistic heritage are reactions against expansions of trade, information, and power - and anomie and xenophobia can be countered by giving substatal ethnicities, minorities and political parties a voice and a vote.

Nicolas Malebranche is now recognised as a major figure in the history of philosophy, occupying a crucial place in the Rationalist tradition of Descartes, Spinoza and Leibniz. The Search after Truth is his first, longest and most important work; this volume also presents the Elucidations which accompanied its third edition, the result of comments that Malebranche solicited on the original work and an important repository of his theories of ideas and causation. Together, the two texts constitute the complete expression of (...) his mature thought, and are written in his subtle, argumentative and thoroughly readable style. They are presented in the distinguished translations by Thomas M. Lennon and Paul J. Olscamp, together with a historical introduction, a chronology of Malebranche's life, and useful notes on further reading. (shrink)